PEPTIDE
MOTS-C
Mitochondrial Open Reading Frame of the 12S rRNA-C
20mg $69MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of mitochondrial DNA. Discovered in 2015 at the USC Leonard Davis School of Gerontology, it represents a novel class of signaling molecules linking mitochondrial function to nuclear gene regulation.
Mitochondrial-Derived Peptide
One of the first identified MDPs, demonstrating that mitochondrial DNA encodes bioactive signaling peptides beyond traditional respiratory chain proteins.
AMPK Pathway Activation
Research indicates activation of AMP-activated protein kinase (AMPK), a master metabolic regulator, through folate-methionine cycle modulation.
Metabolic Research Tool
Studied for its effects on glucose metabolism, insulin sensitivity, and cellular energy homeostasis in preclinical models.
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Investigation of MOTS-c's role in exercise-mediated metabolic adaptations and its translocation to the nucleus during metabolic stress.
| Product Name | MOTS-C |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2174.67 Da |
| Sequence | MRWQEMGYIFYPRKLR |
| Purity | ≥99% (HPLC) |
| Physical Form | White Lyophilized Powder |
| Storage | -20°C, protected from light |
| Certification | Third-party HPLC & MS verified |
| Intended Use | Research and laboratory use only |
