PEPTIDE
IGF-1 LR3
Insulin-like Growth Factor 1 Long R3
1mg $119IGF-1 LR3 is an 83-amino acid recombinant analog of human Insulin-like Growth Factor 1 with an arginine-to-glycine substitution at position 3 and a 13 amino acid N-terminal extension. These modifications reduce binding to IGF binding proteins (IGFBPs), resulting in significantly enhanced bioavailability in research models.
Enhanced Bioavailability
Reduced IGFBP binding affinity results in increased free-form concentration and extended half-life compared to native IGF-1 in research models.
IGF-1R Agonist
Retains full agonist activity at the IGF-1 receptor, enabling study of downstream signaling cascades including PI3K/Akt and MAPK pathways.
Cell Proliferation Research
Widely used in cell culture studies examining proliferation, differentiation, and anti-apoptotic signaling.
IGF-1 LR3: Enhanced potency and reduced binding protein interaction
Characterization of the LR3 analog's binding properties and enhanced potency in cell proliferation assays compared to native IGF-1.
| Product Name | IGF-1 LR3 |
| CAS Number | 946870-92-4 |
| Molecular Formula | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ |
| Molecular Weight | 9111.36 Da |
| Purity | ≥99% (HPLC) |
| Physical Form | White Lyophilized Powder |
| Storage | -80°C recommended, -20°C acceptable |
| Certification | Third-party HPLC & MS verified |
| Intended Use | Research and laboratory use only |
