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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis
Original identification and metabolic characterization of MOTS-c in murine models.
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Peptides · CAS 1627580-64-6 ≥99% Purity · HPLC verified
MOTS-C 10MG
Research-grade MOTS-c peptide. ≥99% purity, third-party verified via HPLC. For research and laboratory use only.
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Identity
Compound information
What is MOTS-C?
MOTS-C (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16 amino acid peptide encoded within the 12S rRNA gene of mitochondrial DNA. First identified by the Cohen lab at USC in 2015, it has been studied in laboratory settings for its role in mitochondrial-nuclear signaling and AMP-activated protein kinase (AMPK) pathway modulation.
CAS Number 1627580-64-6
Molecular Formula C100H151N27O22
Molecular Weight 2174.50 g/mol
Amino Acid Sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Half-Life ~3 hours (rodent plasma)
Source Synthetic mitochondrial-derived peptide
Purity 99.4% (HPLC verified)
Form Lyophilized powder
Solubility Soluble in water, bacteriostatic water
Storage
Stability information
Long-term
−20°C
Lyophilized powder, sealed
Reconstituted
2–8°C
Up to 30 days when refrigerated
Shipping
Room temp
Stable in transit, lyophilized
Protection
Light · Moisture
Store sealed, away from light
Background
About this compound
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of mitochondrial DNA. Studied in laboratory settings for its role in cellular metabolism and AMPK pathway signaling. Each vial contains 10mg lyophilized powder at ≥99% purity.
Specifications:
- Purity: ≥99% (HPLC verified)
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Form: Lyophilized powder
- Storage: -20°C (long-term), 2-8°C (reconstituted)
- Certificate of Analysis available
For research and laboratory use only. Not for human consumption.
Bibliography
Sources & references
02
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline
Examines MOTS-c response to exercise in aging rodent models.
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Mitochondrial-derived peptides in aging and age-related diseases
Review of MOTS-c and other mitochondrial-derived peptides in aging biology.
View source →04
MOTS-c regulates skeletal muscle insulin sensitivity
Skeletal muscle insulin signaling assays in murine models.
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